Herpes Vaccine Failure to Protect Women


Jakarta, Herpes is a sexually transmitted disease that can strike both men and women. But a vaccine that is believed to prevent herpes failed to protect women from disease.

The researchers reported promising vaccine against herpes viruses indicates a failure in large clinical trials. Known efficacy (effectiveness) of this vaccine against herpes disease by 20 percent only. These results are reported in the New England Journal of Medicine.

"We were really disappointed with the results obtained from clinical trials in this large scale," said study co-author Dr. Peter Leone of the University of North Carolina at Chapel Hill, as quoted from ABCNews, Saturday (07/01/2012).

In a large study carried out by imitating the general population of women who are infected do not show the vaccine is effective against herpes simplex-1 (HSV-1), but not for herpes simplex-2 (HSV-2).

In general, HSV-2 is considered more worrisome because they tend to have higher relapse rates compared with HSV-1, and also associated with an increased risk of contracting HIV.

Leone said investigators need to approach different types of vaccines, so that later could find a new vaccine that could work powerful tool for both types of virus.

In this study researchers recruited 8323 women aged 18-30 tahn who do not have antibodies to the virus. The results of analysis studies showed the vaccine had 58 percent effectiveness against HSV-1, but do not have the effect of HSV-2. Overall, this vaccine can protect infection by 22 percent.

"This vaccine has a strong antibody response against HSV-2, but these antibodies may have a blunt impact protection of cellular immune response," said Leone.

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